i think way back when i had headaches when i first used vagifem, but i think im addicted to it now.. Recently i was told i should come off it as i didnt have atrophic vaginitus. i used yes moisturiser, but i just felt dryer and dryer.. boots own brand moisturiser did seem to encourage moisture, and multi gyn actigel, certainly made things comfier.. but to be honest, nothing works as well as vagifem for me.. im not sure a moisturiser or lube would ever work for really bad dryness..