Isn't getting older great! I was fine on Utrogestan for the first 2 years, then I started to feel not as energetic, a bit more anxious and down. Last year the dr told me to reduce my Evorel patch from 100 to 75, and the anxiety got worse, I went back up to 100 to stabilise things. The dr told me to reduce more slowly, which I did, but in January this year my anxiety went horrific, insomnia and depressed mood and ended up at a&e. I am already on anti depressants and have been for 20 years, and have been stable for about 7 years, I assume the lower dose patch made the Utrogestan more effective. I went back to higher dose patch to try to stabilise things, but so far not succeeded, so I'm now on sleeping tablets and anti anxiety meds. I hope things improve soon before I totally lose my marbles!