Hi, yes i think sitting down does make it worse, but i have also found, that if i do nothing and put up with the pain, sometimes it sorts itself out, now i find that really odd. but it never goes away, just worse or bearable.. i have been advised by the doc, twice a week vagifem with moisturizers in between, this has worked for a period of time, then it irritates. then by others doctors not to use moisturizers just vagifem, so in the end, i guess there guess is as good as mine. i suppose as the flora changes up there, we can experience, dryness, thrush, and then inflammation, its an area we cant actually see, so we are really guessing at how to continually treat the soreness, and guess what will ease it, and then the skin gets so sensitive if we try to many things, that we get scared to try anything .. so we really do struggle. i have also experienced the problems with starting a new box of vagifem, as if its not the same as the last box. i have found that boots own brand moisturiser helps sometimes.