Skip to Main Content
 
print media

Home | About | Magazine | Specialists | Forum | Professionals | Sitemap | Shop | Contact

Menopause news




Use of Hormone Therapy in BRCA gene carriers

25 November 2016

A useful article published in "Menopause" has reviewed current information on the effect on breast cancer risk with the use of HRT after removal of ovaries for risk reducing surgery in women who carry the BRCA gene.

BRCA1 gene is associated with risk of breast cancer by age 70 of 60% to 65% and of ovarian cancer of 39% to 59%. BRCA2 gene is associated with risk of breast cancer by age 70 of 45% to 55% and of ovarian cancer of 11% to 17%.

It is known that removal of both ovaries and Fallopian tubes in premenopausal women reduces ovarian, fallopian tube and peritoneal cancer risks by 72% to 80%, and reduces breast cancer risks by 46% to 48% in these women. However, it is also known that early or premature menopause which ensues can cause significant menopausal symptoms and detrimental effects on bone, heart and brain health.

The article explains that studies so far have shown that the risk of breast cancer is not increased with the use of HRT after risk reducing surgery and that young women should not avoid risk reducing surgery because of fear of need for and effect of HRT thereafter. However, studies are limited and further research is required.

Reference:Use of Systemic Hormone Therapy in BRCA Mutation Carriers. Domchek S, Kaunitz A M. Menopause 2016;23(9):1026-1027

[Ref]

< Go Back

<< News Index

For your information...

Menopause + Premature Menopause + Menopause Symptoms + Bleeding Problems + Vaginal Problems + Bladder Matters Menopause and HRT after Hysterectomy Treatments + Diet, Lifestyle & Exercise + Menopause at Work Hormone Replacement Therapy + HRT Preparations + Prescribable non-HRT Testosterone Alternative Therapies + Alternative Techniques Decision Tree Contraception + Osteoporosis + Heart Disease + A to Z of menopause and medical conditions Magazine Shop More +