I find that turmeric (along with vitamin d) reduces my depression. It's an effective anti-inflammatory, and inflammation is strongly implicated in depression. I also found that after about 6 weeks on it, my shoulder and knee pain completely went. I bought the 20,000mg one from Nature's Best and now take one every other day. I took it every day at first, but apparently you shouldn't take that high a dosage long term. That works out cheaper than taking their 10,000mg product every day. I think it's brilliant stuff. Their products (available by mail order/online only) are pure, with effective, guaranteed levels of ingredients, and many are a lot cheaper than H&B. They're a really good, helpful company. Pre covid they sent out any samples you requested. They'll refund you if a product doesn't help, and have a great advice service that you can call or email.