I'm on Evorel, I'm someone who usually reacts to any 'medicenes' I'm given, so I was pretty worried about trying it out, but was surprised that the only effects I felt were very gentle and positive ones.......within 20 mins of putting the patch on I felt this 'cool' feeling across my skin, a little chilly to start with until I got used to it. I realised that I must have been glowing before even though I've never felt I've had hot flushes.
So I'm happy with it. I've noticed a slightly rougher ride by month 3, but I'd introduced Vagifem, and while they say the effects are localised, and I'm sure in most cases they are, I wake with palpitations on the morning that I've had it (and only if I've had it, I know because I'm not using it and generally 'testing' every so often) and also seem to be a bit migrainy (not really awful though) after 12 hours of having used it. But this is not the Evorel, it's the supplemental Vagifem that I took with it.
Re Evorel, I find I feel so much better on the second half of the patches than the first month, but generally better on them than off.