I'm 51. When I was 28 and expecting my second child they found a cyst on my ovary. After my baby was born they removed my ovary because the cyst weighed 10lbs. I then started suffering from panic attacks. I asked the doctor numerous times if it could be down to hormones he kept saying no. When I was 43 I had my second ovary out due to a cyst on it. The gynocologist put me straight on premique 0.625/5mg tablet as I still had my uterus. I started to feel normal almost straight away, my panic attacks stopped. After 5 years on Premique they stopped producing it so the doctor put me on 2mg Estradiol and 5 mg Provera. I never felt as good with anxiety and moods.Then last year I started bleeding and they found my womb lining to be 3 times thicker than it should be. So I had a Mirena coil fitted and put on Estraderm (100) patches. I have just asked to be taken off the patches and to try Premarin as that is the same had what was in premique because I have low mood,anxiety,aching joints,numbness in hand and dangers at night,sinuses have been worse,burning pain in my head along with headaches and just generally felling rubbish. I'm just fed up with how I feel every day. I just want to feel normal. Sorry for long post.