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Author Topic: Is this the right place to discuss compounded hormones?  (Read 77564 times)

Sophie20

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Re: Is this the right place to discuss compounded hormones?
« Reply #165 on: April 12, 2021, 04:10:06 PM »

I personally think it is healthier if everything is discussed in relation to HRT.  What is new on the market? What hasn't been tested sufficiently yet but holds promise.  I am reminded that the Astra Zeneca has only been through short trials, but quite a number of people have taken it; in light of the current situation and the possible implications of not taking it.  For me, it is a case of weighing up different approaches, and having the freedom to undertake my own research given that information or lead.
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #166 on: May 21, 2021, 11:43:33 AM »

For Crispychick.
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #167 on: July 08, 2021, 06:22:28 PM »

I have some good news from the Specialist Pharmacy in London.   They have now developed the sublingual, body identical progesterone drops after clinical trials.   They also have a cream and fast release tablets available.

I'm still working my way through my lozenge prescription but I am going to try the drops when I have finished the batch.

It's good to know there are some different forms of body identical progesterone available now.

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Perinowpost

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Re: Is this the right place to discuss compounded hormones?
« Reply #168 on: July 09, 2021, 03:45:27 PM »

That is good news Mary G thanks for sharing. It’s good to keep abreast of new developments re progesterone x
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Jasmine20

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Re: Is this the right place to discuss compounded hormones?
« Reply #169 on: July 10, 2021, 04:08:19 PM »

Hi MaryG

Thanks for updating us on the options for progesterone.

Do you know what the advantage is of sublingual drops over lozenges  - is it that you can titrate the dose more easily?

I know there are differing opinions about progesterone creams too.

I've gone back on Utrogestan but it's not ideal for me.
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #170 on: July 10, 2021, 05:51:48 PM »

Perinowpost and Jasmine20, yes, it is good that more progesterone choices are available.

The drops will be more user friendly I think and it avoids having to cut the lozenges which come in 200mg tablets and need time to dissolve between the top lip and the gum.   The drops can just be administered under the tongue and that's it!

As for the cream, it is a bespoke cream and this is available at various doses and therefore stronger than the stuff available online.   They have trialled all the products and their effects on the endometrium and they do keep the lining thin as do my 50mg lozenges.

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Hurdity

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Re: Is this the right place to discuss compounded hormones?
« Reply #171 on: July 11, 2021, 08:09:13 AM »

I have some good news from the Specialist Pharmacy in London.   They have now developed the sublingual, body identical progesterone drops after clinical trials.   They also have a cream and fast release tablets available.

I'm still working my way through my lozenge prescription but I am going to try the drops when I have finished the batch.

It's good to know there are some different forms of body identical progesterone available now.

It ia always good to hear about different forms of progesterone being developed for the benefit of those who don't get on well with the ones currently available.

I have some things to say about this. First I would hope if there have been clinical trials then these will be published in a peer reviewed paper to be avialble to the whole scientific/research community. If it does work well for different doses of oestrogen and over the typical periods of time that is needed to study the effectiveness in protecting the endometrium, with minimal side effects - then hopefully a pharma compa ny could develop a product for commercial use and available on NHS. My main gripe with all of this is firstly the lack of (published) trials and secondly that all of these sorts of products are really only available to the very few who can afford the high prices charged so anything to make these products more wudely available to all has to be good.

From a biological point of view I wonder about the value of sub-lingual delivery of progesterone in terms of side effects. With oestrogen - a spray ( or sub-lingual - though I don't know about what is available here?), the main aim is to get it into the blood stream as quickly as possible I think.

However with progesterone - I would intuitively think that taking it sub-lingually would cause a rapid burst/spike of progesterone in the body, which, because of its instability in the body will decline over the course of the day - so actually leading to more artificially induced diurnal fluctuations (daily peaks and troughs) and therefore potentially more side effects. Because progesterone is not stored anywhere then I'm sort of thinking that a big dose would still be needed to counter this breakdown - eg when compared to vaginal use which goes straight to the uterus and in my view from what I've read, is the best method of delivery to protect the endometrium. I can imagine there would be fewer side effects from sub-lingual use than oral but not compared with vaginal maybe?

If the proposed sub-lingual delivery is more frequently than once per day this would make more sense if women were able to remember to take it, because the ovary pumps out progesterone normally in regular pulses throughout the day (?and night) - once per day of a large dose is unnatural hence we (many of us) experience moreside effects.

Re cream - the same argument applies. Publish the data showing efficacy and fewer side effects then pharma develop a standard product available to all if possible!

Hurdity x
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #172 on: July 27, 2021, 08:51:52 PM »

For Mindfulmoomims.
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Mindfulmoomins

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Re: Is this the right place to discuss compounded hormones?
« Reply #173 on: July 28, 2021, 07:12:17 AM »

Thank you Mary xx
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #174 on: September 22, 2021, 06:42:04 PM »

I have just ordered my first prescription of 50mg progesterone sublingual drops.   

I will keep you posted on here as to my progress!
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CrispyChick

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Re: Is this the right place to discuss compounded hormones?
« Reply #175 on: September 22, 2021, 06:57:47 PM »

How do they differ from wgat you were taking before Mary? Lozenges??? What's the benefit?
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Mary G

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Re: Is this the right place to discuss compounded hormones?
« Reply #176 on: September 22, 2021, 07:07:40 PM »

Crispychick, the dose will be exactly the same but the drops will be more user friendly.   I like the lozenges but they take about half an hour to dissolve between the top lip and the gum whereas the drops go straight under the tongue.   

I haven't read the instructions yet but I'm told you simply deposit a drop under your tongue and make sure you don't swallow for a couple of minutes and job done!   Sounds good.

I'm always keen to try new products when they become available.

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CLKD

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Re: Is this the right place to discuss compounded hormones?
« Reply #177 on: September 22, 2021, 07:23:55 PM »

I believe that some angina tablets are deposited under the tongue for fast treatment?

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CrispyChick

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Re: Is this the right place to discuss compounded hormones?
« Reply #178 on: September 23, 2021, 12:50:00 PM »

Fabulous. I certainly take spray vitamins and I love them. Always squirt into my cheek. Maybe I'll try under tongue!
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Perinowpost

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Re: Is this the right place to discuss compounded hormones?
« Reply #179 on: September 23, 2021, 01:52:03 PM »

Sounds good MaryG let us know how you get on x
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