I also went through it in my late 30's, have you considered the transdermal route, esp since you are going to be on it for so much longer,something like Oestrogel/Femigel, it is the most natural method of taking HRT and I have had no side effects whatsoever, only positive effects, you can adjust the pump dosage as well, I would strongly consider that with Utrogestan, which is also Bio Identical, for early meno. All the best.