Menopause Matters Forum
Menopause Discussion => All things menopause => Topic started by: dangermouse on January 09, 2026, 06:17:00 PM
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I just had a genetic methylation test and I have the MTHFD1 TT gene (strong) CT (medium), MTR (strong), PEMT (strong) and the COMT (medium) plus high transmitter ones.
So main thing is that this shows I do not metabolise oestrogen (and serotonin) very well and I am more prone to low progesterone levels.
I have ordered the MTHR supplement as this puts the folate back but in a way I should be able to process it.
Does anyone else have similar results and have issues tolerating oestrogen supplementation and their own oestrogen spikes?