Menopause Matters Forum
Menopause Discussion => All things menopause => Topic started by: Nanookster on June 10, 2025, 07:15:28 PM
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Hi everyone,
I’m hoping someone might share their experience or thoughts on this. I’ve recently been put back on Bijuve (1mg estradiol + 100mg progesterone, daily) after struggling emotionally with 14 days/month of 200mg Utrogestan. I’m now also using one pump of Estrogel every morning, because I feel so much better on a bit more oestrogen.
So my daily hormone intake is roughly:
1.75–2mg of estradiol (from Bijuve + Estrogel)
100mg of daily micronised progesterone (from Bijuve)
I’ve read some sources saying the ratio of oestrogen to progesterone doesn’t matter — that 100mg of progesterone daily is sufficient for endometrial protection, regardless of a slightly higher oestrogen dose. But I’ve also seen others suggest that adding extra oestrogen should mean adjusting the progesterone too.
Has anyone else been on this kind of combo?
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Hi if the progesterone in Bijuve is the same dosage as Utrogestan, then 100mg can be used up to 3 pumps of Oestrogel or a 75 patch or 3mg oral oestrogen.
Any high doses of oestrogen need a dosage of 200mg of Utrogestan / micronised progesterone.
This is guidance from the BMS.
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We are all different and it is difficult to say a particular dose of one formulation equates to a particular dose of another across the board due to individual variation in absorption and metabolism.
Additionally the amount of progesterone that controls one person's endometrium at a given level of estrogen may be insufficient for another, so generally manufacturers and prescribers tend to err on the side of caution and have everyone on a dose that protects the highest risk women, even though this means others are over treated.
You are still on a low dose and in all probability that dose of progesterone should cover you.
However my advice to anyone on a more individualised regimen, particularly when mixing and matching different formulations or adding extra estrogen to a fixed dose combined product would be to get a scan once a year or so to make sure you aren't developing hyperplasia.
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Thanks @Dotty - what is considered a big estrogen dose?
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https://thebms.org.uk/wp-content/uploads/2024/12/01-BMS-GUIDELINE-Management-of-unscheduled-bleeding-HRT-NOVEMBER2024-A.pdf
Hi pages 13 and 15 give you the doses and how much progesterone is advised.
4 pumps of gel or 100 patch is regarded as a high dose.