Menopause Matters Forum

Menopause Discussion => Postmenopause => Topic started by: Kathleen on February 16, 2025, 04:54:12 PM

Title: I Feel Another Experiment Coming On.
Post by: Kathleen on February 16, 2025, 04:54:12 PM

Hello ladies.

I am thinking of trying another experiment and I thought I would post here first.

I have had a lot of family visiting this weekend including my gorgeous two and a half year old grandson. It's been lovely but I am so ridiculously tired I can barely keep my eyes open, in fact I have worried that I may burst into tears from exhaustion!

I may try to reduce Utrogestan to see if that helps to reduce the fatigue but of course that means coming off Sandrena gel. If the night sweats etc return then I will be tired from that!

My Dr has prescribed Pregabalin for my nerves but I wonder if that is also adding to the fatigue?

When I have the house to myself I will decide what to do and I will report back to the forum.

Btw why is everything so annoyingly difficult to figure out?

Take care ladies and wishing you all well.

K.

Title: Re: I Feel Another Experiment Coming On.
Post by: bombsh3ll on February 16, 2025, 06:47:25 PM

Why would you have to stop the estrogen gel?

If micronised progesterone doesn't suit you there are plenty of non-drowsy alternatives.

As a first step have you tried taking it vaginally? This bypasses the gut and hence avoids conversation to supra physiological quantities of allopregnanolone.

Title: Re: I Feel Another Experiment Coming On.
Post by: Taz2 on February 16, 2025, 10:16:33 PM

Fatigue is one of the commonest side effects of pregabalin during the first few weeks of treatment. I'm not sure how long you've been on it for?

Taz x

Title: Re: I Feel Another Experiment Coming On.
Post by: Kathleen on February 17, 2025, 07:26:54 AM

Hello ladies.

Taz2 - I started on Pregabalin about mid October on a very low dose, 25 mg per day. I was told that this low start was to see how I tolerated it. My dose has been gradually increased and I have now been taking 50 mg twice daily since the middle of January.

I have had times of huge tiredness before and if I haven't been able to rest or nap I have managed to push through. I feel that in general I sleep well but I often wake up tired.

I will check in with my GP to see what they think about the Pregabalin dose.

bombsh3ll -   I have used Utrogestan orally a while a go and then vaginally when this was advised by Newson Health.  When I moved back to my GP surgery for my HRT the vaginal route was frowned on and I was advised to use it orally. I thought I would give it another try. If this is making me more tired then I will attempt vaginally again and see if that feels better.


Thanks for the replies ladies,  I have to resolve this tiredness somehow so I will keep experimenting.

Take care ladies and wishing you well.

K.

Title: Re: I Feel Another Experiment Coming On.
Post by: Dotty on February 17, 2025, 07:58:22 AM

Hi I suffered with exhaustion when my oestrogen was low. The right dose of Oestrogel sorted it.

It’s all a bit of a minefield !

Title: Re: I Feel Another Experiment Coming On.
Post by: Kathleen on February 17, 2025, 09:05:18 AM

Hello Dotty

I totally agree! You are fortunate that you found the right HRT combination.
I may be doing the wrong thing by experimenting again but things are not good atm so it's worth a try.

Thank you for your reply and I wish you well.

K.