Menopause Matters Forum

Menopause Discussion => All things menopause => Topic started by: Nellf on June 27, 2023, 06:46:21 PM

Title: Progesterone intolerance
Post by: Nellf on June 27, 2023, 06:46:21 PM
Any one had any experience with this?  After deciding to go private, i found that i was intolerant to progesterone.  My HRT regime changed to Estrogen patches plus utrogestan.  Initially I felt like my old self again.  still experiencing flushes my Patch was upgraded from 50 to 75 and was told that I would have to increase the utrogestan to 200mg per night.  I now feel that I'm back where I started.  Really low mood, no interest in anything and generally miserable.  I have spoken to the consultant who recommended that I reduce my progesterone to 100mg at night.  However this may not be enough to protect the lining of my womb from thickening.  If I have any bleeding then I should see my GP right away.  Just wondering if any others are suffering the same thing and how to manage it.  Have also thrown testosterone in the mix as my libido is non existant.  What happens when you are progesterone intolerant ?   How can you manage HRT.  I have read that the only solution is to have a hysterectomy, and continue on estrogen therapy.  Interested to hear others experiences with this :)
Title: Re: Progesterone intolerance
Post by: Flossieteacake on June 27, 2023, 06:49:44 PM
If you are okay with 100 ultrogestan then I would not say you are progesterone intolerant. :) If you wish to you could carry on at 100 and have regular scans to check your womb lining, although some people would disagree with me there. Quite a few members cannot tolerate more then 100 ultrogestan. If you wish to you could put 'ultrogestan' into the search bar and have a browse of all the threads.

There is also the option to try a different progesterone too.
Title: Re: Progesterone intolerance
Post by: discogirl on June 27, 2023, 07:12:31 PM
Hi Nellf

I agree with flossieteacake if your ok on 100mg of utro you may not be progesterone intolerant.

I found with myself that even taking utro vaginally gave me constant feelings of dread so i changed the type of progesterone.

There are lots of other progesterones out there that you can take xxx
Title: Re: Progesterone intolerance
Post by: Nellf on June 27, 2023, 07:40:39 PM
Yep I seem to feel OK on 100mg.  Interested to find out about different progesterone.  It's a struggle with my GP sometimes.
Title: Re: Progesterone intolerance
Post by: Flossieteacake on June 27, 2023, 07:58:54 PM
This link will show you all the different HRT preparations. :)

https://www.menopausematters.co.uk/treatment.php
Title: Re: Progesterone intolerance
Post by: sheila99 on June 27, 2023, 08:46:47 PM
The usual dose for conti hrt is 100mg. The BMS seems to recently changed the guidelines to 200mg. Vaginal use is supposed to be more effective as more gets to where it's needed. If I was in your shoes I'd use 100mg vaginally and have a scan in 6 months to check the lining is still thin.
Title: Re: Progesterone intolerance
Post by: Nellf on June 28, 2023, 03:49:25 PM
Sheila 99.  I would love to try it vaginally, but I suffer from chronic cystitis.  I can't even use vagifem because it causes irritation.  So I'm a wee bit scared to try it that way.  I'll see how the 100mg orally goes and take it from there.  Thanks for the advice.  Its so good to hear other womens experiences and advice 😊
Title: Re: Progesterone intolerance
Post by: Ermin2trude on June 28, 2023, 04:01:26 PM
What estrogen patches are you using? I found Evorel gave me night sweats and heavy irregular bleeds plus low mood. I switched to Estradot and all symptoms went away. Might be worth trying before you get too despondent with HRT.
Title: Re: Progesterone intolerance
Post by: Nellf on June 28, 2023, 09:18:17 PM
I'm taking Estraderm MX 75.  Been OK on them.  Low mood etc seems to kick in with introduction of more progesterone it's a minefield
Title: Re: Progesterone intolerance
Post by: Ermin2trude on June 29, 2023, 08:51:50 AM
I’m on a continuous regime and told to take 100mg every night, however it may not control bleeding and I could have some irregular bleeds and /or spotting. If I don’t want any bleeding then I would need to up it to 200mg. Both my GP and menopause specialist think that 100mg is the way to go unless I really don’t want a bleed. So I don’t see why you can’t take the 100mg if it suited you before.

There are other progesterones which suit some people better. Have you tried Provera?
Title: Re: Progesterone intolerance
Post by: Nellf on June 29, 2023, 10:58:04 AM
Thanks Ermin2trude.  I'll see how I go on the 100mg for now.  I'm trying it on the morning as I'm having real issues with sleep.  Have also thrown testosterone into the mix to just for good measure 😊  Once im settled on that and if symptoms persist, I'll have a chat with me GP about other progesterone.  It's just getting it right that's the struggle.
Title: Re: Progesterone intolerance
Post by: Hurdity on July 02, 2023, 09:57:19 AM
If you are okay with 100 ultrogestan then I would not say you are progesterone intolerant. :) If you wish to you could carry on at 100 and have regular scans to check your womb lining, although some people would disagree with me there. Quite a few members cannot tolerate more then 100 ultrogestan. If you wish to you could put 'ultrogestan' into the search bar and have a browse of all the threads.

There is also the option to try a different progesterone too.
Hi Floss

Just a friendly note to say, you might like to know that the product is spelt "Utrogestan" so a search for "ultrogestan" won't reveal many threads though I just had a look and there are nore than I thought  ;D

Hurdity x
Title: Re: Progesterone intolerance
Post by: Hurdity on July 02, 2023, 09:59:44 AM
...or you could try 200 mg for 12 days per 28, ie cyclically? Or do this once in a while to shed any lining built up on 100 mg, or take 100 mg on a "continuous" basis for 25 days out of 28 which is the original licensed dose designed to shed any lining that might have built up?

Hurdity x
Title: Re: Progesterone intolerance
Post by: Flossieteacake on July 02, 2023, 10:16:38 AM
If you are okay with 100 ultrogestan then I would not say you are progesterone intolerant. :) If you wish to you could carry on at 100 and have regular scans to check your womb lining, although some people would disagree with me there. Quite a few members cannot tolerate more then 100 ultrogestan. If you wish to you could put 'ultrogestan' into the search bar and have a browse of all the threads.

There is also the option to try a different progesterone too.
Hi Floss

Just a friendly note to say, you might like to know that the product is spelt "Utrogestan" so a search for "ultrogestan" won't reveal many threads though I just had a look and there are nore than I thought  ;D

Hurdity x

Oops. I struggle with spelling and make many mistakes.
Title: Re: Progesterone intolerance
Post by: discogirl on July 02, 2023, 10:24:02 AM
That's okay flossieteacake, I struggle with spelling as well  :)
Title: Re: Progesterone intolerance
Post by: Flossieteacake on July 02, 2023, 10:32:12 AM
That's okay flossieteacake, I struggle with spelling as well  :)

Luckily it is not just me.  :)