Menopause Matters Forum
Menopause Discussion => All things menopause => Topic started by: Kady2022 on July 22, 2022, 07:37:03 PM
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Hi guys
Does anyone on here have a genetic chromosome condition?
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R U able to explain further ?
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Hi Kady,
Welcome to the forum!
Probably more of us do than we realise, but I don’t believe I do.
Are you referring to a specific one that you know you have or just a general question?
X
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Is your query relevant to your other thread?
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R U able to explain further ?
I have a chromosome translocation so basically it’s mean my body aborts at 8-12 weeks of pregnancy was just wondering if anyone else has a genetic chromosome condition that can bring on early menopause
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Is your query relevant to your other thread?
Yes
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Sorry Kady, I have no knowledge of this condition.
Do hope that other ladies on MM might be able to help.
Good luck and keep posting! X
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That's very sad and must be difficult. Or send a PM to Dr Currie for which there is a charge? She has a wide range of knowledge regarding womens' health as well as having colleagues who she could raise the issue with.
Let us know what you decide?
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Hi Kady, the short answer to your question is no, you are not predisposed to have an early menopause due to being a carrier of a balanced translocation, and the key word here is 'balanced'. If that's your case, it means you have one or two chromosomes that have a piece of DNA in a different position, but it doesn't code any genetic material, that's why you don't have any symptoms or signs related to the translocation, but when your cells undergo meiosis in order to produce eggs, some of the eggs are going to lack important genetic material and when fertilised they will end up in miscarriage or stillbirth. It's very rare for a translocation to affect a gene and when it does it's going to produce symptoms and in some cases these will be related to reproduction, as in translocations affecting the X chromosome or genes in other chromosomes that are important for reproduction, and in these cases premature ovarian failure or early menopause can occur, but this is extremely rare. This article explains this in more detail. https://bnrc.springeropen.com/articles/10.1186/s42269-021-00523-z
I've just read your other posts and it looks like you are having symptoms of an early menopause. In that case it would be easier to tell if it could be related to the translocation if you could specify which translocation you have.
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We are a Mine ........... genetics has always fascinated me. Not that I can remember the ins and outs ::)
Keep posting Kady2022
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Hi Kady, the short answer to your question is no, you are not predisposed to have an early menopause due to being a carrier of a balanced translocation, and the key word here is 'balanced'. If that's your case, it means you have one or two chromosomes that have a piece of DNA in a different position, but it doesn't code any genetic material, that's why you don't have any symptoms or signs related to the translocation, but when your cells undergo meiosis in order to produce eggs, some of the eggs are going to lack important genetic material and when fertilised they will end up in miscarriage or stillbirth. It's very rare for a translocation to affect a gene and when it does it's going to produce symptoms and in some cases these will be related to reproduction, as in translocations affecting the X chromosome or genes in other chromosomes that are important for reproduction, and in these cases premature ovarian failure or early menopause can occur, but this is extremely rare. This article explains this in more detail. https://bnrc.springeropen.com/articles/10.1186/s42269-021-00523-z
I've just read your other posts and it looks like you are having symptoms of an early menopause. In that case it would be easier to tell if it could be related to the translocation if you could specify which translocation you have.
Thanks for the reply….
So I’m a carrier of a balanced translocation between one of my X chromosomes and one of my number 7 chromosomes which could results in my baby either having too much or too little genetic information and it would most likely result in either a miscarriage or a possibility that my baby having both significant developmental and health problems
Hope this helps
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Thank you, Kady. In this case, you have a slightly higher chance of having hormonal (including premature ovarian failure) and autoimmune problems, depending on the exact location of the X;7 translocation. One good thing about translocations involving the X chromosome is that there is a random process of inactivation of one of the two X chromosomes in females (called Lyonization), which produces a milder phenotype (signs and symptoms). In the case of translocations involving the X chromosome, this process may be nonrandom and most cells will inactivate the translocated X, so the bearer of a balanced translocation sometimes is not affected at all.
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Thank you, Kady. In this case, you have a slightly higher chance of having hormonal (including premature ovarian failure) and autoimmune problems, depending on the exact location of the X;7 translocation. One good thing about translocations involving the X chromosome is that there is a random process of inactivation of one of the two X chromosomes in females (called Lyonization), which produces a milder phenotype (signs and symptoms). In the case of translocations involving the X chromosome, this process may be nonrandom and most cells will inactivate the translocated X, so the bearer of a balanced translocation sometimes is not affected at all.
So the balanced translocation can bring on early menopause?
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In theory, yes. I would need to know the exact location of the translocation to be more precise.
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In theory, yes. I would need to know the exact location of the translocation to be more precise.
They never told me the location of the translocation just that I was a carrier of it
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High FSH blood test results would confirm you have premature ovarian insufficiency.
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I’ve done a fsh test at home or should I say several and they have all come back positive
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Hi Kady, all FSH tests will be positive. You need to go to your GP and ask for FSH and estradiol blood tests. This will have to be repeated in 2 to 4 weeks. If estradiol is consistently low and FSH consistently high, you will be diagnosed with Premature Ovarian Insufficiency and your GP will prescribe you HRT. The fact that you have a genetic translocation doesn't change that, but it is a good reason to perform the tests IF your GP is reluctant.
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What would you like to learn? You have an apparently complex question so starting new threads is unlikely to draw any other responses :-\
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Hi again Kady, I hope you can sort it soon. I'm sure there are other woman out there with the same questions, balanced translocations are very common amongst cases of infertility. Maybe you will have more replies on forums like mumsnet. Keep us posted.
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I've been on MM for many years and don't remember your type of query.
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I've been on MM for many years and don't remember your type of query.
I have posted its under womens health
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I have been here for many years and there hasn't been your type of query other than your questions in your threads, there are no other threads when I searched MM Forum.
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I have been here for many years and there hasn't been your type of query other than your questions in your threads, there are no other threads when I searched MM Forum.
I did post it
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Via the Forum search facility there are no historical threads regarding your chromosome condition, any Members who have similar would by now have responded. I suggest as others have, that you contact your GP to get a referral to an appropriate Consultant.
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CLKD - can’t you leave Kady alone. She’s a new member and deserves more respect. Your attitude is not good for other new members to see.
It’s not bothering anyone else so if it’s bothering you, just don’t read them or post on them.
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I really, really didn't want to comment but CLKD I believe your behaviour here is very much out of order towards a fellow member of the forum, you have no idea the anguish the original poster might or might not be going through.
You are not a moderator its not your place to dictate to others how they post new threads.
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Hi Kady, the short answer to your question is no, you are not predisposed to have an early menopause due to being a carrier of a balanced translocation, and the key word here is 'balanced'. If that's your case, it means you have one or two chromosomes that have a piece of DNA in a different position, but it doesn't code any genetic material, that's why you don't have any symptoms or signs related to the translocation, but when your cells undergo meiosis in order to produce eggs, some of the eggs are going to lack important genetic material and when fertilised they will end up in miscarriage or stillbirth. It's very rare for a translocation to affect a gene and when it does it's going to produce symptoms and in some cases these will be related to reproduction, as in translocations affecting the X chromosome or genes in other chromosomes that are important for reproduction, and in these cases premature ovarian failure or early menopause can occur, but this is extremely rare. This article explains this in more detail. https://bnrc.springeropen.com/articles/10.1186/s42269-021-00523-z
I've just read your other posts and it looks like you are having symptoms of an early menopause. In that case it would be easier to tell if it could be related to the translocation if you could specify which translocation you have.
balanced chromasome X, 7 translocation
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Hi Kady2022, Uptick is not a member of the forum any more (unfortunately). I have found this article (actually just an abstract) about your condition and it says 'X-autosome translocations are frequently associated with primary or secondary ovarian failure'. How are you doing?
https://pubmed.ncbi.nlm.nih.gov/19663602/