Menopause Matters Forum
Menopause Discussion => All things menopause => Topic started by: Postmeno3 on September 28, 2021, 06:20:22 AM
-
Hi there,
I'm looking for advice from very postmenopausal ladies over 60 on systemic HRT who might help me understand why I'm experiencing very heavy sweats on waking, whether during the night to occasionally need to wee or first thing on surfacing? I don't sweat at any other time. I started on Evorel25 in May and was upped to Estradot37.5 three months later. I noticed almost no changes at all in symptoms on the first dosage, but symptoms seem worse on this increased one, particularly these sweats, but also with fatigue, concentration, mood, energy, vaginal sensitivity/bladder urgency plus mild panic/flusteredness with any deadline or scheduled timings. With my next review looming, I'm puzzled to know what to request as, essentially, all these symptoms I had before have worsened. The sweats are new and concerning as they affect the quality of my sleep or how my day goes if with the morning wakening. To me, it sounds like quite marked fluctuations due to an ongoing or heightened imbalance which I need to know what it's indicating and how to address it? I think testosterone could help, but with the oestrogen deficiency symptoms seemingly all over the place, that's an unlikely outcome. Has anyone any experience of this sense of going backwards, even with a new symptom, in my case sweats and what helped you?
Feeling a bit despondent.
Many thanks in advance.
💚
-
Sorry cant help with the HRT and related symptoms as im not on full HRT just local but the sweats have been a problem for me too. I never suffered with them before (65 and 11 years post meno) until i had the AZ vaccine in March then again in June, they have only recently stopped this last couple of weeks. There's alot of threads regarding this and disruption caused to HRT regimes that were previously fine. Also younger women have reported changes to their menstruation after the vaccine. Assuning you have had the vaccine, have you considered this?
-
Just to add, that is still a very low dose of oestrogen so you have plenty of room to increase the dose further/ try a different delivery method eg gel.
-
Hi Deirdre. I had the Pfizer and the second one was a long time ago. I think it's insufficient systemic oestrogen and no idea what is being absorbed. Thanks again.
-
Thanks, Gnatty. Yes, I think still plenty scope and earlyish days after many, many years depleted.
-
Almost 60 & 9+ years postmenopause. The horrible, intense night sweat package has been my most resistant symptom since very start of peri in mid 40s & one that continues to wreck sleep whatever I try. Currently on same brand & dose of oestradiol patch as you. When I add in the progestogen cyclically the night symptoms get markedly worse & I reason this could perhaps be the opposing effect on oestrogen, or the fact that prog raises body temp. Oestrogen is said to increase the stress/waking hormone cortisol though, so perhaps something for both of us to bear in mind.
I am on testosterone, this does seem to have helped with sleep & has definitely helped other symptoms, so may be worth trying when you can. It's not stopped my night sweats but my first menopause specialist told me years ago that it should improve sleep. Still fine tuning my HRT but it's complicated by other conditions.
My feeling is it may be that you need more oestrogen (some of your other symptoms suggest this, don't they), but equally that your body could well be struggling to adapt to the relatively new influx of hormones & especially now at a higher dose. I think you've posted in the past that you had a long break from HRT & are very sensitive to medication. Mine throws a hissy fit at every change, whether up or down.
I also sense that the deeper sleep I get as my oestrogen dose increases, together with the mildly sedative effect of some progestogens, means I sleep further into overheating episodes, so that by the time I wake suddenly with them they are very intense. What I mean is that my sleep is unsatisfactorily lighter on lower oestrogen but that means I wake more easily as I begin to overheat, so can remove covers before the heat becomes truly infernal. So the accompanying shock to the system is less. Either way, sleep is far from adequate! Have you noticed that when you are actually asleep your sleep has deepened on the increased dose - could the intensity of overheating scenario with associated stress response be the same for you?
If you can manage to get your oestradiol level tested to see what absorption you're getting, this may help you work out next step. You mention your instinct that fluctuations may be behind the night symptoms, so you could maybe discuss with your prescriber trying a different method - gel/spray?
Sorry Postmeno3, this can be such a bumpy ride when in later years we could really do with it being sorted pdq.
Wx
-
Thanks. Sleep is of a very good quality on the higher dose. My understanding is pumping out a lot of cortisol depletes oestrogen and so there could be a case for increasing the oestrogen to have sufficient to manage or deplete the cortisol output. Maybe someone with the "chemical interaction" expertise will come along to inform us more! 🤞
-
This is interesting (small study), but perhaps explains why some women feel better on a form of progesterone:-
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663529/
"Conclusions
Estrogen administration elevated cortisol levels, but this effect may be moderated by progestins."
Wx
-
I'm 60 now and over the past year, I have noticed that I need a lower dose of oestrogen and if I go too high, I get loose bowels and it triggers my silent migraines. It's a definite change and my migraine specialist said that in my case, if I take more oestrogen than my body needs, it will set off gastric migraines.
Fortunately I can take a lower dose of oestrogen (1 pump of gel) and be symptom free but it's certainly a physiological change around the age of 60.
Could you be the complete opposite and need a higher dose of oestrogen to be symptom free?
What type of progesterone don't you use?
-
Without bloods, it's very difficult to assess what's what. If I understand the study correctly, (thanks!) patches have little or no effect on cortisol even reducing it as opposed to tablets which increase it. It also seems to imply, if I'm right, that longer use reduces the cortisol scenario even further. I also see this is a hugely underinvestigated area! That's poor. It makes one wonder about increased anxiety, reactive sensitivities etc etc etc! However, I am guessing I need a shed load of oestrogen (progesterone off the table due to hysterectomy). Calling Taz, Hurdity, Elkwarning????? Hmmmmmm.....plenty food for thought meantime!
-
It's important to have blood tests fairly regularly to check your hormone levels post menopause, it's the only way to know how well you are absorbing your HRT. You could try to get them on the NHS.
-
If only, Mary G. Sadly, they refuse point blank, even at the specialist clinic (NHS). I've posted before about not understanding this dictate for postmenopausal women, where, presumably, the confusing fluctuations of peri and meno which could lead to misleading information, are much less prevalent if at all. Absorption issues are clearly key. Is there a magic wand to be waved for the relevance of this to be given more attention? Surely it can only be beneficial all round for this group, not to mention cost-effective, less time-consuming, less harrowing and just plain common sense? Unless I'm missing something......
-
Sorry Postmeno3, I hadn't re-read this study in detail before posting the link this morning - had simply bookmarked it some time ago & just scanned it today. Yes, confusingly it cites other studies that gave mixed results as to the effect of oestrogen administration on cortisol levels (inc one that found transdermal had no effect), but it also mentions that transdermal has some, if lesser effect:-
"This may help explain why oral ERT more consistently elevates total cortisol levels compared to transdermal ERT."
I've done a quick trawl this afternoon & there is mention that cortisol levels are higher in postmenopausal women than pre, but I haven't had time to look into it further.
I suspect a dysfunctional cortisol response is involved in my repeated early awakenings (hence suggesting you might be the same), so I'd really like to get to the bottom of this. Although I'm much better in other ways for oestrogen & testosterone replacement the night sweats are frustratingly still very disruptive & eliminating them would make a massive difference to my life. So I really sympathise with your situation.
There are quite a few women on here who report feeling calmer for progesterone (I'm not one of them) & while I understand your point that this is not usually thought necessary after hysterectomy, perhaps you could discuss it with your menopause specialist if, as your earlier thread on the topic suggested, you still feel you may benefit from it.
If you feel you do need a shedload of oestrogen though, does that mean your night sweats were even worse before resuming HRT? If they were less problematic on 25mcg than 37.5 (as I thought you meant in your original post) it certainly confuses the picture!
I hope you get some helpful advice from other members.
Wx
-
The "sweats", I feel, are different to "night sweats" in that they only happen if and when I wake, once awake. They do not wake me. During the night, they start after I wake if I need to go to the loo or immediately after waking naturally for the day. They are much worse on the higher dose, indeed was not aware of them at all on the lower dose. I have nothing during the day at all, even on waking from a nap. There must be something about hormonal "rhythms", I'm guessing, perhaps more active at certain times? I know about cortisol firing us up for the day, technically and there may be something worth investigating more fully there in relation to "sex hormone" levels? This doesn't account, though, for the loo call sweat much earlier. Hmmmmm.....🤔
-
I have noticed that the NHS say certain procedures are not necessary ie hormone blood tests and uterine scans because they can't afford to offer them to women.
Far too many women are taking far more progesterone than they need and having dreadful side effects because of the lack of uterine scans and far too many post menopause women are on the wrong type/dose of oestrogen because they have no idea what they levels are. It's vital to known your levels post menopause, particularly if you need oestrogen for bone protection.
Why not be honest and admit it's because of financial constraints?
-
Ah yes, that's the thing Postmeno3 - sometimes I'm already way too hot when I wake suddenly in the small hours, but what also often happens is that I find I'm suddenly awake, initially relaxed & wondering why I'm awake & then the intense overheating follows within a minute or so. Often the worst is the latest: the 5am. On only 25mcg oestrogen I only usually manage to sleep on & off until around 3-3:30am & then I'm too alert to get back to sleep (same as without HRT). I also don't feel as though I'm on oestrogen at only 25mcg - I don't feel the obvious benefits at that dose that I get on 37.5. But on 37.5, despite the horrible sweats persisting, I can more often get back to sleep in between as I'm generally drowsier. I think the intensity of sweats may be worse for me on 37.5mcg than on 25mcg, but cumulatively I tend to get more sleep on the higher dose as the quality when I am actually asleep is better. Not a consideration for you as you don't take prog, but progestogens really ramp up the heat & the stress response that comes with it, further disrupting my sleep so that I absolutely dread that phase of the cycle. Not sure whether any of that gels with your experience.
-
Yes, I suppose I'm trying to differentiate between sweating (as in drenched in perspiration) and overheating. I'd love to find out more about how different delivery methods work and even "brands" for the sensitive as Evorel50 might be the upgrade I need given there was at least no setback on Evorel25. Perhaps there are some ladies with more experience than me in this regard. There might also be a place for better stress and nutrition management. I'm just confused and curious about the worsening on a higher dose and needing to have a clearer idea of absorption and levels so that I might know better what I'm dealing with so that I can work with it as best I can.
-
Yes, we all absorb differently so if you feel the brand may be wrong for you, then returning to Evorel could be next step. Personally I get better absorption by far from Estradot than Evorel (4 x more bloods have shown), but it may be quite different for you.
I prefer to say "overheating" in relation to my getting so hot at night as I don't produce sweat, simply get intensely hot & that seems to badly stress the body. Not sweating means it takes longer to cool down so it plays merry hell with sleep!
I absolutely share your frustration re the NHS position on testing of sex hormone levels postmenopause & have messaged you with links to the private hospital group I use for mine, just in case this is an option for you. I completely understand it may not be though, & sympathise if that's the case. We are not well off but can just about afford to do this by foregoing other things.
Wx
-
Thanks. That's really interesting about the absorption. Without testing, of course, hard to tell as you say. Does anyone else, postmenopausally, feel they absorb better on Estradot, or, vice versa, on Evorel? It would be useful to get a concensus, though, of course, we're all so different and absorption maybe depends on having/reaching a certain level first? 🤔
-
Hi Postmeno3,
You said, "The 'sweats,' I feel, are different to 'night sweats' in that they only happen if and when I wake, once awake. They do not wake me."
Another cause for the sweating could be low blood sugar in the morning (nocturnal hypoglycemia). While sleeping at night, your blood glucose level may be falling too low. Adrenaline is produced in response to the declining blood sugar level which causes sweating.
Depending on the severity, other symptoms include nightmares or sleep disturbances, headache, lightheadedness or dizziness, anxiety, pounding heart, dry mouth, tingling or numbness of the mouth, shaking, hunger, blurred vision.
-
Wow! Thanks for this. So where does the HRT come into it? I have only had it since upping to Estradot37.5 in the past few weeks, nothing on the Evorel25 in previous weeks. I understand Estradot may be faster absorbed and more strongly than Evorel. Is it nothing to do with this, or something causing more rapid fluctuations affecting or linked to blood sugar reactions?
-
Changes in your hormone levels, as well as age-related changes, affect how your body responds to insulin and can trigger fluctuations in your blood sugar level, up or down.
-
Good point Ana21. Blood sugar probs are said to become more likely at menopause. But didn't you post elsewhere Postmeno3 that you'd recently had blood sugar issues ruled out, or am I thinking of someone else? I had the impression you were already nutritionally clued up, but I agree with Ana21, definitely worth looking into if you haven't? If you want to have a discerning Google, there are lots of articles on how sex hormones affect blood sugar & it's been discussed on many threads on here too.
I've long suspected nocturnal hypoglycaemia could be a factor in my own sleep probs & have spent a lot of time researching it, but my Endocrinologist doesn't think it likely & all attempts to safeguard against it with habitually careful attention to diet haven't really improved things. Doesn't help us that inadequate sleep also makes us prone to destabilised sugar control - catch 22!
Wx
P.S. Ana21 - you've posted again while I was writing this!
-
Yeah, so my blood sugars are fine and nothing in my nutrition has changed. The only thing that's changed is the introduction of Estradot which may just be too much of a "hit" to my very sensitive systems. You seem to be experiencing overheating as part of your hormonal fluctuations, on Estradot also, Wrensong? Something is awry somewhere for us both, it seems. So, is it a case of too immediate an influx? Do we need a trickle rather than a deluge?
-
Yes, Postmeno3, currently on same dose of oestradiol from Estradot as you, but symptoms are not exclusive to Estradot, I've also had them on other types of HRT. Worse on the progestogen phase of my cycle & onset was with perimenopase, starting in my mid-40s, years before HRT. The most resistant symptom for me & one of the hardest to live with. I don't know what the answer is, but I'm sure working on it!
-
Hello Postmeno3 and Wrensong!
Good to hear you've ruled out blood sugar issues. I'm low-carb but my father had Type 2 diabetes, so I'm mindful of the symptoms. Earlier in the year, I experienced night sweats and HFs with heavy sweating while on Estradot 50 + Prometrium/Utro 100 mg. I had never experienced such profuse full body sweating. I was wearing a dress with no stockings and sweat was literally running down my legs. It looked like I had wet myself. It wasn't the summer heat. I had been in an air-conditioned building all day. My symptoms had to become quite extreme before my doctor ordered a blood test to check my estrogen level, which confirmed I wasn't absorbing the patch. I wish they would routinely test postmeno women to ensure they are absorbing transdermal estro. I wasn't warned that absorption could be an issue, so I wasn't looking for the signs. In retrospect, I had symptoms indicating I wasn't absorbing the patch well or consistently since I started HRT at the end of Feb 2020. Many women do well on it, but I'm not one of them. I hesitated to post because I don't want to increase your anxiety. Hopefully, Postmeno3, your morning sweats will disappear as you adjust to the new patch.
-
Thanks! Yes, it's all a bit of a mystery without knowing about absorption and levels. So, did you find out why the sweating was related to poor absorption? I've been on retreat this week and should, if anything, have had less that had the potential to be challenging instead of things getting worse. I've been on the Estradot37.5 for two months now so I think it's safe to say it's not agreeing with me, but hard to understand why.
-
Hello Ana21, that degree of sweating sounds extremely uncomfortable. Have you found a regimen that suits you better since then? The testing issue can be so frustrating - when I first started HRT some years ago I was nearly 2 years on Evorel Conti before we found when it was finally agreed to test my oestradiol, that I was absorbing very poorly, explaining inadequately controlled symptoms. Being a 50mcg patch my then doctor thought it should be sufficient, but turns out I was getting less than half the expected absorption. My HRT is now overseen privately & I arrange bloods myself.
-
Postmeno3,
I think I can answer your question as to why my sweating was related to poor absorption. Broken thermostat. The hypothalamus, located deep in the brain, is the body's thermostat. That's one of its many jobs. Estrogen plays a role in temperature regulation and messaging.
Hot flushes are complicated and a bit ridiculous. From what I've read, it's not our estrogen level that matters as much as the drop. For example, we don't experience hot flushes before puberty. A hot flush only occurs when a brain that has had estrogen has it taken away. It's all about the drop. The faster the drop, the more severe the symptoms. That's why surgical menopause causes more HFs and more severe symptoms in general. Normally, menopause is a gradual process.
Another oversimplification, but here goes. When our estrogen drops, our thermoregulatory system becomes extremely sensitive to minor changes in temperature and it responds in an exaggerated manner. We develop a wonky thermostat. It thinks our temperature is higher than it actually is.
A hot flush is the body's attempt to cool itself. Women may experience a wave of heat and redness in the face and chest. This occurs because the blood vessels dilate and blood is shunted to the surface of the skin in an attempt to dissipate some of the non-existent heat. There's reduced blood flow to the brain, the heart rate goes up which can feel like anxiety, and we sweat. After all this, body temperature drops and some women experience chills. It can be an exhausting roller-coaster ride.
To my demented thermostat, the house was on fire.
***
Wrensong,
You also had to wait a long time to get confirmation that you weren't absorbing well. I've only been on tablets for a few days and my doctor plans to reduce my current dose once my estrogen level is up, as well as switch tablets. Changes ahead. It will be many more months before I can tell whether I've found a regimen that suits me. I hope I can find a transdermal that works for me in the future. That would be ideal. I'm also hoping my doctor will be less reluctant to order blood tests in the future.
Have you found a regimen that works for you? How often do you have blood tests and do you test for estrogen only or other hormones as well? My estradiol level was <40.
-
Thanks. So, yeah, I have been thought to have M.E. and broken thermostat/hypothalamus is very much related to that, too, but I feel I may have been misdiagnosed or not entirely accurately potentially because of circumstances, diagnostic process etc at the time eighteen years ago. If it is M.E., I believe it was hormonally (not virally) triggered and would have needed a very different treatment plan, probably endocrinologically. Diagnosis came at the perhaps significant number of age 51. So, the journey has been long and complex since. I am now 69. However, I just read that, in rare cases, Estradot can cause carb intolerance!!!!!! These sweats, only on waking at those two times, could be linked to that rare side effect. Blimey, this is fascinating but a zillion piece jigsaw puzzle!
-
Ah, Ana21, you may have a way to go yet then in terms of best fit. Yes, I think most of us hope a transdermal regimen will be the one, but if you find you feel well on oral & stabilise on that it will give your body a chance to recover, so you'd be in a better place to move on & try something else then perhaps. More resilient. Or you may find you feel so well that you don't want to rock the boat. Time will tell I guess.
To answer your question, I'm still trying to find a really good HRT fit. I used it for 2+ years a few years postmenopause then had a longish break, then started again 2.5 years ago. I'm better with HRT than without, but increasingly struggling with progesterone in all its forms & having a cycle also seems difficult to combine with my thyroid regimen, which is atypical & complicates matters. I need to persevere with HRT for QOL as I have other chronic conditions, inc osteopenia.
I'm currently arranging bloods about every 6 months, but also depends on whether my HRT or thyroid replacement doses change, or symptoms suggest something needs adjusting. Depends on what we're concerned about as to what endocrine bloods I have tested but usually full thyroid function, oestradiol & testosterone. I've had oophorectomies & testosterone is important for me.
I sympathise with your rock bottom oestradiol level, mine was also <44 when first tested postmenopause, when I still had ovaries.
Postmeno3 However, I just read that, in rare cases, Estradot can cause carb intolerance!!!!!!
Can I ask was that Estradot specifically or oestradiol replacement in general? If the former, can you post a link please? Seems odd if Estradot in particular.
-
Yes, it was specifically for Estradot and came from a pharmaceutical company. I've tried to send you the link, sections of which you might have more skill than I to put up here, if relevant. Thanks!
-
Hi postmeno3
I've had a quick look at this thread. Sorry to hear about your sweats. I have no complex analysis to offer....
First though - my own experience - I have tried Estradot (many years), and then when the shortages began, Estraderm (briefly), then Elleste Solo (for a year or two?), and the last few months was put on Evorel. I have never noticed the difference between any of them ( apart from size and stickability).
In terms of sweats - and patch types - the only time sweats have returned has been when I have reduced the dose of whichever patch I am using. Also a while ago when I increased patch dose too quickly I also had the return of sweats/flushes.
When I changed to gel for a few months I also had the return of flushes/sweats but didn;t stay long enough to tweak the dose because I knew that patches worked.
In addition - some women - me included sometimes, can get increased flushes and sweats on the progestogen phase of their cycle if they are on cyclical HRT - and some women take an increased dose to counter this. Not applicable in your case.
Remind me whether you have your ovaries?
Also other metabolic issues re thyroid function ( apols if this has already been covered elsewhere - I've not been on the forum for a few weeks)? Have you had blood tests to rule out this?
However, I just read that, in rare cases, Estradot can cause carb intolerance!!!!!! These sweats, only on waking at those two times, could be linked to that rare side effect. Blimey, this is fascinating but a zillion piece jigsaw puzzle!
It would be unlikely that only Estradot would cause carb intolerance and I'm not sure what they mean by this? If it was reported by the pharma it would be as a consequence of their studies into their own product. All patches release estradiol and don't contain any different active ingredient.
In terms of types of sweats and overheating - many women experience these differently at different levels of oestrogen depletion eg women may report some degree of overheating during peri-menopause and ask (on here for example) if this is the start of hot flushes. Only later do they develop into flushes and sweats. This is what happens with me - eg if I reduce oestrogen dose - I start to overheat at night, and toss and turn as a result - but not sweats as such - but eventually these and flushes, return.
My normal intuitive reaction to your situation (having ruled out other causes for your sweats) would be that you need higher oestrogen - because your own oestrogen has fallen or the dose is too low). However at your age (approx similar to mine) I would want to know your history a bit more (Sorry I've forgotten!). ie ve brief rundown of what hsppened when eg hysterectomy, age, HRT tried, when your symptoms ( flushes etc) started.
Yes I gather from reports on here and from Louise Newson that ME may be wrongly diagnosed - and may well be due to hormonal issues - notably insufficient oestrogen or tesosterone, or thyroid problems.
I would also have sympathy with the blood sugar issues. Blood tests may not show anything. I always have normal blood sugar but I definitely have blood sugar problems - severe "reactive hypoglycaemia" at times - which to all intents and purposes is like true hypoglcaemia in terms of symptoms. I almost always wake hungry, but I have a sleep issue too in that I sleep very heavily now - so it doesn't wake me in the night. I often have a small bowl of yogurt or something before I go to bed as I'm often hungry at bedtime too!
My suggestion if you haven't done so already is to see if your sweats are caused by anything else (thyroid notably), possibly eat something before you go to bed ( slow release), ensure your diet is healthy (reduce quick relase carbs and sugars), and then think about increasing the oestrogen dose? Also depending on your past history.
Hope that helps though I have not come up with anything concrete nor have I read any secientific papers for months!
Hurdity x :)
-
Perfect, Hurdity, thanks. Yes, thyroid tested very recently, all ok. I have one remaining ovary as a result of a hysterectomy nearly thirty years ago. I think you're right that the oestrogen is dropping off and for some unknown reason at those times. Otherwise, at 69, very healthy BP, bmi etc. Only resumed HRT in May of this year after being forced to come off it, as many on here in that misinformed period were, about 15 years ago. Thanks again! Very much appreciated! 😊
P.S. Yes, I had become aware that Dr. Newson is bringing to awareness the misdiagnosis issue and in a recent survey I was asked to complete, the team got back to me to say they were abreast of "countless" women in this "sad position".....BUT, that's a whole other thread (hence the P.S.!).
-
Hi Postmeno3, thought you might be interested in this extract from the link below as it talks about night sweats starting after awakening (as per your recent experience) rather than as cause. As mentioned earlier, I seem to get both!
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/414566
"Multiple previous studies have found an association between hot flushes and subjective sleeping disturbances, leading some researchers to conclude that hot flushes disrupt sleep; however, several laboratory-based studies using objective measures have documented that hot flushes and night sweats tend to follow, rather than precede, arousals and awakenings from sleep.33,34 Rather than being a cause of sleep disturbances, therefore, hot flushes may be a comorbid symptom of menopause that shares common underlying triggers."
Wx
-
Yes, it was specifically for Estradot and came from a pharmaceutical company. I've tried to send you the link, sections of which you might have more skill than I to put up here, if relevant. Thanks!
Postmeno3, thanks for the link. Here it is, with the extract I think you were referring to, in case anyone is interested:-
https://www.medicines.org.uk/emc/product/7234/smpc#gref
"4.8 Undesirable effects
The following adverse drug reactions have been reported from clinical trials and from post-marketing experience with either Estradot or oestrogen therapy in general:
Metabolism and nutrition disorders
Very rare: Decreased carbohydrate tolerance."
As it was the SmPC for the 75mcg patch you sent me that's what I've posted here, but I did check the one for the 37.5 mcg patch (which you & I both use) to be sure the very rare carb issue they mention wasn't a result of the relatively high (75mcg) dose. The wording is the same for the lower strength we both use. I thought I'd remembered reading somewhere it could be an issue with all oestrogen products & from what they say above, this finding may not be specific to Estradot trials.
Wx
-
Thank you for the info, Postmeno3, Wrensong and Hurdity.
-
You could have written this post for me. ;D This is exactly what is happening to me. I've been on Estrodiol gel 4 pumps and ultrogestan 200mg daily for 6 months.
I feel so much better apart from the sweats which just won't stop but as you say only after I wake up they don't wake me up!!!
I'm so glad to have found someone else that has the same problem.