Menopause Matters Forum
Menopause Discussion => All things menopause => Topic started by: GypsyRoseLee on October 12, 2016, 12:08:01 PM
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Have just discovered there is a new HRT on the market called Duavive. It contains estradiol but instead of the dreaded progesterone, it contains bazadocifene to shed your womb lining.
It's in tablet form, so sadly isn't transdermal. But it is excellent news for progesterone intolerant women.
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Hi, thank you so much for posting that news, GypsyRoseLee. That is music to my ears as I have come to the conclusion that I must be progesterone into!erant. I took Utrogestan for eight nights during which I had such extreme PMS that I felt suicidal. I stopped it !ast Thursday as I felt like I was going mad. There could be some hope on the horizon! Xx
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Brilliant. Thanks so much!!! Xxxx hope u r doing well
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Oh damn, I thought it was bio identical oestrogen. What a shame.
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It would be good if it could be marketed as a separate progesterone product. I don't see why this shouldn't be a option in future.
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I also looked it up. It looks like a continuous combined therapy? I.e one same combined pill every day. Not for peri ladies then.
Milamam
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I also looked it up. It looks like a continuous combined therapy? I.e one same combined pill every day. Not for peri ladies then.
Milamam
:'( was all excited till I read your post!
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I really don't understand why they don't have medroxyprogesterone (Provera) available transdermally. Norethisterone is available in patch form, so why not the progestin that seems to be better tolerated by women?
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;D Stellajane
Thanks GypsyRoseLee - yes I think this was launched earlier in US in 2013/2014 and I think there was some publicity about trials etc. Is it now available in UK?
It's brand name is DUAVEE and as the others say sadly does not contain estradiol - I really despair. I also think the manufacturers are really sneaky now calling them "conjugated oestrogens" and missing out the equine just to blind women to the true constituents.
Dana I don't think any of the progesterone derived progestogens are available transdermally and I presume it is to do with the molecular structure and stability? Not sure really - although I bet commercial considerations come into it as well. I know that progesterone itself has to be micronised, and not produced as a normal tablet because it is unstable.
Yes of course dydrogesterone should be available separately, ditto lower doses of utrogestan, ditto vaginal use licensed. Big pharma has a lot to answer for...
Hurdity x
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Oh, Stellajane! You know it!!! ;D
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My specialist told me that 'bioidentical' progesterone cannot be produced transdermally, as the patch would have to be enormous to achieve the same bioequivalance as the capsule, a real shame.
Rhiner
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The Chelsea Panay Clinic suggested this last year as I'm highly progesterone intolerant - initially I was interested but then I discovered that it's equine derived - so a big no no - also prefer transdermal. Let's hope they continue working on 'next generation' HRTs. Tiered dose of Utrogestan would be a start.
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Is the oestrogen from a mare much worse for you than bio identical oestrogen?
It seems so odd they'd put old fashioned oestrogen in a new product?
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Thanks Stella. Why on Earth didn't they use bio identical oestrogen???
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I think that they are still widely used in the UK too. We have to remember that we are a very small proportion of women on here compared to the wider population of meno ladies happily using all sorts of hrt out there ::) Albeit that we are very important ! ;D
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Cost and the fact its been around for years and years as in if it aint broke..... ;)
Two friends of mine swear by prempak c !
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My chemist told me once that she still dispenses more premarin than estradiol. As dazned said, we have to remember this forum represents a very small proportion of the world's meno population.
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;D Stellajane
Dana I don't think any of the progesterone derived progestogens are available transdermally and I presume it is to do with the molecular structure and stability? Not sure really - although I bet commercial considerations come into it as well. I know that progesterone itself has to be micronised, and not produced as a normal tablet because it is unstable.
Hurdity x
Yes I'm sure you're right. Let's hope things change as more women realise the benefits of hrt and it becomes more financially attractive to big pharma.
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Why would they refuse something though when it obviously works for thousands of women ! :-\
I remember when at my worse I told gp Id take shoe polish if it made me feel better,infact would have tried anything ! ::)
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Many women who take equine estrogen either don't know or simply don't care how it is produced.
http://horsefund.org/premstoppers-home.php
http://www.all-creatures.org/alert/alert-20160312.html
Personally I would NOT take "anything".
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I wasn't happy taking Premarin as my Mum had DVT whilst taking it (and the Consultant who prescribed it knew this)! Also, I had awful dizziness on it which seems to be problematic and doesn't settle for some women according to many posts on this subject over at the Hystersisters forum.
It works very well for some women (upon my research, particularly those in surgically induced menopause) I think because it has androgenic effects too. A full break down of WHAT is exactly in Premarin can be found on the SurMeno blog.
I also found out that Wyeth have been very aggressive about blocking the release of 'generic Premarin ' in the past. So does this mean that they have now been unsuccessful and this new product is effectively generic Premarin (or Prempro which was their combined HRT)?
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I am presently taking Duavive (Duavee in USA) - just started my second month!
If you look back at my posts you will see I have had somewhat of a nightmare journey after becoming allergic to Progesterone!
I started Menopause at 47 and am now 58 - the hot flushes/sweats have increased and become more severe with time (15 in a day).
I have tried every other option including Gabapentin at quite a high dose, which did reduce the flushes for a time, but then stopped working.
I did discover Duavee on the Internet and actually posted about it, but presumed it would be sometime before available. However, when I approached my Consultant about it, he agreed I would be a prime candidate for it due to my severe allergy to Progesterone and agreed to look into obtaining it for me - this was then made easier due to it recently becoming available in the UK.
It obviously would not have been my preferred HRT, but I was so desperate for some relief from the debilitating hot flushes, which were getting worse rather than better!
It is early days, but already the flushes are reducing dramatically and also the severity of them, so I am grasping this HRT with both hands lol !!
At long last I feel there is a light at the end of the tunnel.
Will keep you informed x
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Glad you have found something that seems to work for you,as I said each one of us is different. ;)
I personally couldn't get on with utrogeston after kicking up stink to get it because I thought it was the be all and end all ! Then found out it wasn't, for me anyway. ::)
Here's hoping you continue to improve . :)
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Tina1957, I've just read some of your older posts and you mentioned silent migraines - migraine aura consisting of visual disturbance but no headache and this is exactly what I get when using all types of synthetic progesterone (including the Mirena coil) and also Utrogestan in high doses. You are the first person I have come across on this site who suffers from the same thing!
I didn't have silent migraines when using synthetic progesterone pre menopause, it was only when my own hormone levels dropped that they started. Like you, I think I am allergic to synthetic progesterone because when I was on the pill in my 20s, I had a constant nasal drip and was tested for allergies but not progesterone so that might be what caused it - I have never had any problems with my own progesterone. How did you find out that you are allergic to progesterone?
I hope the Duavive works for you, what exactly is it and is it completely free of progesterone? Also, how much oestrogen does your tablet contain?
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Morning ladies my doctor just mentioned this HRT wonder how anyone on it is getting on. Xx
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As far as I know it's not available in this country yet but only in US but correct me if I'm wrong. Maybe some of our friends across the pond have tried it?
Hurdity x
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Ah right, my doctor said she would have to do more research before giving me it maybe she is unaware you can't get it yet xx