There are a few ladies on this lovely forum who have been through an early meno, I also tried the natural route for about a yr but went onto bio identical HRT at 40, you may want to try this if you dont get on the with your tablets. The rub on gel works beautifully combined with the Utrogestan (progesterone part ) used vaginally. You keep cycling as you should do and feel very normal and healthy, and will hopefully be able to come off the AD's which many ill informed GP's like to prescribe for early meno, when in fact all your body requires is what it should be naturally making, hormones! You need not worry about any dangers, up until 50 even a bit later, you are only replacing what your body is needing so no added health risks. All the best.