Ann. I started this a while back, i had breast tenderness for about two weeks, then it went away, i have it back now, but it's such a common prob on hrt that it may be my normal hrt. I also had really bad thrush, which i was prone to, got that treated and it's never come back. A few ladies found an initial infection type thing, but they'll tell their own stories i'm sure. Benefits well outweigh the symptoms for me.